Furthermore vomiting, dry skin or maculopapular rash, ocular toxicity, mucositis, edema, neutropenia, anorexia, symptomatic blood creatine phosphokinase (CPK) elevation, alanine aminotransferase (ALT) increase, anemia, hypertension, constipation, non-cardiac chest pain, and pruritus were other frequent TRAEs [2, 3, 5, 33, 34, 71, 72]. This evidence concerns the gene PIK3C2A and hypertensive disorder.