RNPEP and metabolic syndrome: Furthermore, using a multivariate binary logistic regression model (backward stepwise method) including other variables such as age, dyslipidemia, neurological evolution, previous stroke, functional dependence, and 3-month mortality, we found that CNS-ApB concentrations at baseline (< 9 h post-stroke) together with dyslipidemia and mortality were independent predictors of penumbra failure (Table 2).