Additionally, we also evaluated associations between mRNA expression levels of PANX1 and APP and OS of patients with liver cancer in the KM plotter, and found that patients with lower mRNA expression levels of PANX1 had a better liver cancer OS (HR = 6.44; 95% CI = 1.55–26.81; log-rank P = 0.003, Fig. 4C); and higher of mRNA expression levels of APP had a better liver cancer OS (HR = 0.30; 95% CI = 0.13–0.69; log-rank P = 0.003, Fig. 4D). This evidence concerns the gene APP and liver cancer.