As shown in Table 3, compared with patients with no NUGs, those patients with one or two NUGs had a worse OS in the subgroup of aged ≤ 47, male, never smokers, never drinkers, with AFP level > 400 ng/mL, with cirrhosis, no embolus, and with BCLC stage B/C (P < 0.05 for all). The gene discussed is AFP; the disease is Cirrhosis.