APP and hepatocellular carcinoma: To provide a better estimation of the accumulative effect of significant SNPs on survival of HBV-related HCC patients, we combined unfavorable genotypes (i.e., PANX1 rs3020013 AA + GA and APP rs9976425 TC + TT) into a genetic score to divide all patients into three groups based on the number of unfavorable genotypes (NUG) (0, 1, and 2 unfavorable genotypes).