Finally, although our results indicated that PANX1 rs3020013 and APP rs9976425 may play an important role in HBV-related HCC survival, the exact molecular mechanisms are unclear, and more mechanistic experiments are needed to clarify the underlying molecular mechanisms of PANX1 rs3020013 and APP rs9976425 in the progression of HCC. The gene discussed is APP; the disease is hepatocellular carcinoma.