IRF2 and pregnancy disorder: For the pregnancy disorder upregulated regulons and target genes, we identified that the predicted dNK2/3-associated IRF2 and IRF7 targets were enriched with preeclampsia upregulated genes (IRF2 LOP p = 9.2 × 10–5, 19-fold; IRF7 EOP/LOP (p = 5.0 × 10–5/5.6 × 10–5), 7.1-fold / 8.6-fold) (Fig. 6C, Supplementary Table S7).