For the pregnancy disorder downregulated regulons and target genes, for dNK1, we found that that predicted FOXP2 targets were enriched with genes downregulated in missed abortion (RPL) [19], (p = 1.8 × 10–4, tenfold, LAYN, EGLN2, FOXP2, LAMA4 and SPARC) and predicted RREB1 targets were enriched with unexplained recurrent pregnancy loss underrepresented cluster [12] (p = 1.4 × 10–4, 36-fold, SYNGR1, CCND2 and UBE2F). The gene discussed is SPARC; the disease is pregnancy disorder.