Elevated levels of SPIN1 protein have been observed in various types of cancer, such as prostate cancer, pancreas cancer, breast cancer, colon cancer and ovarian cancer, etc (Chen et al, 2016; Chew et al, 2013; Fang et al, 2018; Lv et al, 2020; Zhou et al, 2021). Here, SPIN1 is linked to Familial prostate cancer.