Elevated levels of SPIN1 protein have been observed in various types of cancer, such as prostate cancer, pancreas cancer, breast cancer, colon cancer and ovarian cancer, etc (Chen et al, 2016; Chew et al, 2013; Fang et al, 2018; Lv et al, 2020; Zhou et al, 2021). This evidence concerns the gene SPIN1 and malignant colon neoplasm.