Meanwhile, the results of GM130 showed no significant changes, which is consistent with the unchanged GM130 expression in the SN of PD patients22. By further constructing DA cells stably knockdown and expressing GRASP65, we demonstrated that GDNF promotes Golgi aggregation and enhanced DAT glycosylation to facilitate DAT transport to the plasma membrane by upregulating GRASP65 in PD cells. Here, GDNF is linked to Parkinson disease.