Alternatively, the suppression of the lipid flippase solute carrier family 47 member 1 (SLC47A1) enhances ferroptosis by favoring the ACSL4–sterol O-acyltransferase 1 (SOAT1) pathway over the ACSL4–LPCAT3 pathway, leading to the production of PUFA cholesterol esters in pancreatic cancer cells [102]. Here, ACSL4 is linked to familial pancreatic carcinoma.