The major nucleic acid sensors involved in DNA recognition are TLR9, cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING), absent in melanoma 2 (AIM2) and Z-DNA-binding protein 1 (ZBP1), with the three latter ones being cytoplasmic DNA sensing mechanisms [27, 28]. The gene discussed is STING1; the disease is melanoma.