On the other hand, ANXA1 and ANGPTL4 secreted by myxoma cells may bind to their corresponding receptors on macrophages, such as FRP1 and SDC2, to promote M2-like polarization of macrophages.58,59 These findings suggest that the interactions between myxoma cells and macrophages may sustain the growth of mucinous tumor cells (Fig. 6f). Here, ANXA1 is linked to mucinous neoplasm.