The communication between macrophages and myxoma cells involved several signaling pathways reported to promote macrophage M2-like polarization, such as ANGPT, ANNEXI, ANXA1, VISFATI, and GAS signaling pathways 53,54and tumor growth-promoting pathways, such as EGF and PDGF signaling pathways 55,56(Fig. 6c). The gene discussed is ANXA1; the disease is myxoma.