EREG and myxoma: Results showed that EREG, PDGFC, and NAMPT, which were secreted by macrophages, may bind to their corresponding receptors on myxoma cells to promote the proliferation and survival of myxoma cells 49,57(Fig. 6d), of which PDGFC was predominantly expressed in M2-like macrophages, while EREG is primarily expressed in M1-like macrophages (Fig. 6e).