EGFR and neoplasm: Wu et al. elucidated that the Wnt signaling pathway can crosstalk with other signaling pathways (such as Notch, EGFR, etc.), and this network interaction significantly impacts tumor metastasis.91 Vashi et al.92 found that the persistent activation of STING induces the activation of the non-canonical NF-κB signaling pathway, promoting immune evasion and tumor metastasis.