NFKB1 and colorectal carcinoma: Mechanistically, TNFAIP3-mediated NF-κB signaling pathway is stimulated by primary CRC-derived ITGBL1-enriched EVs, activating fibroblasts.111 Hsin-Jung Wu et al.112 identified that through intercellular communication mediated by exosomal miRNAs, focal adhesion kinase (FAK) activation in CAFs facilitated breast cancer cell migration and metastasis.