Through comprehensive transcriptomic sequencing and metabolomic analysis, the study unveiled that HKDC1 mediates abnormal lipid metabolism in gastric cancer cells, identifying a novel regulatory axis involving HKDC1, G3BP1, and the protein kinase PRKDC.194 Chen et al.195 unveiled how ACSL4, an enzyme linked to fatty acid metabolism, plays a critical role in promoting HCC progression. Here, HKDC1 is linked to hepatocellular carcinoma.