LBR and breast cancer: It was found that miR-222 was upregulated in CAFs compared to normal fibroblasts (NFs) in breast cancer.102 Lamin B receptor (LBR) was identified as a direct miR-222 target and, since the LBR knockdown phenotype miR-222 overexpression and the LBR overexpression expression phenotype miR-222 knockdown, so are functionally related.