CD8A and colorectal carcinoma: For example, our previous study has shown that MGP stimulates CD8+ T cell exhaustion by triggering the NF-κB pathway, which results in CRC liver metastases.125 In addition, based on CRISPR/Cas9 screening, CHSY1 induces CD8+ T cell fatigue by activating the succinate metabolism pathway, which results in CRC liver metastases.125 Xiaocui Zheng et al.126 presented a single-cell landscape of the ovarian cancer (OC) ecosystem, highlighting five tumor-relevant areas such as malignant ascites and omentum metastases.