This results from varying NO homeostasis regulation, which in turn controls the expression of vascular endothelial growth factor in a NO-dependent feedback loop.120 In a gastric cancer tumor co-culture system, gastric cancer cells induced lymphatic vessel endothelial cells (LECs) to secrete CXCL1 via the NF-κB pathway. The gene discussed is CXCL1; the disease is gastric cancer.