Through extensive metabolomic and transcriptomic analyses, RIOK3 promotes the expression of the arginine transporter solute carrier family 7 member 2 (SLC7A2), enhancing arginine uptake and activating the mechanistic target of rapamycin complex 1 (mTORC1).204 Chen et al.205 developed a multifunctional nanoplatform (HN-HFPA) that remodels the immunosuppressive tumor microenvironment (ITM) in TNBC through arginine metabolism modulation in TAMs. This evidence concerns the gene RIOK3 and neoplasm.