ARHGEF37 and neoplasm: Importantly, ZCL278, a specific inhibitor of Cdc42, significantly inhibited the adhesion of HCC cells overexpressing arhgef37 to endothelial cells, as well as adhesion and extravasation in alveoli, thereby inhibiting HCC lung metastasis in animal models.115 Boris Strilic et al.116 showed that tumor cells from humans and mice cause endothelial cells to undergo programmed necrosis, or necroptosis, which encourages tumor cell extravasation and metastasis.