HIF1A and renal carcinoma: GATA3 overexpression reduced the migration of both IL6-stimulated and renal carcinoma cells, and it markedly decreased STAT3 phosphorylation.105 Xu et al.106 demonstrated that by attaching to particular receptors, CAF-derived CCL5 prevented the ubiquitination and degradation of hypoxia-inducible factor 1 alpha (HIF1α), preserved HIF1α under normoxia, upregulated the downstream gene zinc finger enhancer-binding protein 1 (ZEB1), and induced EMT, thereby confirming its capacity to encourage HCC lung metastasis.