Silencing of GOT2 facilitates tumor migration and invasion by augmenting glutaminolysis, nucleotide biosynthesis, and glutathione synthesis, thereby reprogramming glutamine metabolism.206 Song et al.207 discovered the role of Angiopoietin-like protein 4 (ANGPTL4) in regulating glutamine metabolism and fatty acid oxidation, significantly influencing energy metabolism and tumor metastasis in NSCLC. The gene discussed is ANGPTL4; the disease is non-small cell lung carcinoma.