In lung cancer, the acetylation level of histone H3K27ac is closely associated with the invasiveness and metastatic potential of tumor cells.59 Similarly, ubiquitination, which plays a crucial role in protein degradation, impacts the metastatic ability of CRC by modulating p53 protein function.60 Moreover, multiple studies have demonstrated that phosphorylation of EGFR proteins significantly influences HCC metastasis.61 This evidence concerns the gene EGFR and neoplasm.