Moreover, Bcl-2 specific siRNA inhibition can specifically curtail target gene expression, promoting pancreatic cancer metastasis.44 LncRNA PCAT19’s interaction with HNRNPAB in prostate cancer and the androgen insensitivity or AR antagonist activation of lncRNA NEAT1 in prostate cancer cells stimulate prostate cancer growth and metastasis by influencing associated cell cycle genes.45,46 Recent studies have highlighted the role of circRNAs in human cancers. This evidence concerns the gene AR and prostate cancer.