PKMYT1 and colorectal carcinoma: In non-small cell lung carcinoma (NSCLC), lncRNA PKMYT1AR counteracts β-catenin protein ubiquitination degradation facilitated by the PKMYT1AR/miR-485-5p/PKMYT1 axis, maintaining CSC and propelling NSCLC metastasis.42 LncRNA IGFBP4-1, identified to have elevated expression in lung cancer tissues, may foster cell proliferation and metastasis by modifying cellular energy metabolism.43 In CRC, lncRNA CCAT2 represses miR-145 augmentation and inversely modulates miR-21, facilitating CRC cell proliferation and differentiation.