Mechanistically, TNFAIP3-mediated NF-κB signaling pathway is stimulated by primary CRC-derived ITGBL1-enriched EVs, activating fibroblasts.111 Hsin-Jung Wu et al.112 identified that through intercellular communication mediated by exosomal miRNAs, focal adhesion kinase (FAK) activation in CAFs facilitated breast cancer cell migration and metastasis. Here, ITGBL1 is linked to breast cancer.