VEGFA and cancer: Mechanistically, transcription factor ETV4 enhances BCa cells-derived CXCL1/8 to recruit TANs, leading to the increase of VEGFA and MMP9 from TANs, and then facilitating lymphangiogenesis and lymph node metastasis of BCa.158 Deng et al.159 demonstrate that collagen-induced DDR1 activation in cancer cells is a major stimulus for CXCL5 production, resulting in the recruitment of TAN, the formation of NETs, and subsequent cancer cell invasion and metastasis.