The JAK/STAT, Wnt/β-catenin pathways influence tumor cell migration, invasion, and adhesion through various mechanisms, while also regulating tumor immune suppression, cytokine levels, and interacting with lipid and glucose metabolism, collectively promoting tumor metastasis.77 The JAK/STAT pathway is implicated in the regulation of the inflammatory response, while inflammation plays a pivotal role in tumor metastasis.78 Furthermore, within the JAK/STAT pathway, there exist negative regulatory signals such as SOCS1, PIAS and PTP. Here, SOCS1 is linked to neoplasm.