Mechanistically, TNFAIP3-mediated NF-κB signaling pathway is stimulated by primary CRC-derived ITGBL1-enriched EVs, activating fibroblasts.111 Hsin-Jung Wu et al.112 identified that through intercellular communication mediated by exosomal miRNAs, focal adhesion kinase (FAK) activation in CAFs facilitated breast cancer cell migration and metastasis. The gene discussed is ITGBL1; the disease is colorectal carcinoma.