This modification is facilitated by DNA methyltransferase.52 Notably, NOP2/Sun RNA methyltransferase 3 dependent RNA modifications, specifically -5-methylcytosine (m5C) and its derivative 5-formylcytosine, have been implicated in promoting mitochondrial mRNA translation, thereby enhancing tumor metastasis.53 In breast cancer, the progression and metastatic capability are heightened by BAF155/SMARCC1 methylation, a core component of the SWI/SNF chromatin remodeling/tumor suppressor complex. Here, SMARCC1 is linked to breast cancer.