Restoring aberrant angiogenesis and metastasis in REDD1 deficient TAMs requires decreasing glycolysis.169 Moreover, macrophage STING signaling enhances NK cell-mediated suppression of CRC liver metastasis through the 4-1BBL/4-1BB pathway170 and exosomal ANGPTL1 from Kupffer cells reduces CRC liver metastasis by modulating secretion patterns and counteracting MMP9-induced vascular leakiness.171. The gene discussed is ANGPTL1; the disease is colorectal carcinoma.