The MAPK signaling pathway is also involved in multiple signal transductions that promote tumor invasion and metastasis.93,94 Liu et al.95 showed that the activation of the Wnt/β-catenin signaling pathway can promote the activation of the NF-κB, PI3K/Akt and Hedgehog signaling pathway in tumor cells, thereby further enhancing the invasiveness and metastatic potential of tumor cells. The gene discussed is PIK3CA; the disease is neoplasm.