NFKB1 and neoplasm: The NF-κB signaling pathway plays a multifaceted role in tumor metastasis by promoting the invasiveness and metastatic capacity of tumor cells, maintaining pro-survival signals, and interacting with immune cells in the tumor microenvironment, leading to a chronic inflammatory state associated with malignant transformation, angiogenesis, metastasis, and therapy resistance.62 Fan et al. have extensively discussed the multiple roles of NF-κB in tumor metastasis.