DDIT4 and gastric cancer: One potential treatment target for preventing tumor spread in gastric cancer is CAP2, a crucial protein that mediates the interaction between tumor-associated macrophages and gastric cancer cells.167 CCL18 secreted by TAMs enhances breast cancer metastasis via PITPNM3.168 REDD1 deficiency in TAMs leads to the formation of smoothly aligned, pericyte-covered, functional vessels, which prevents vessel leakiness, hypoxia, and metastases.