Tregs are a distinct subset of CD4+ T cells that facilitate early tumor growth by modulating the host immune response and subsequently promote tumor dissemination to the bone marrow and lymph nodes.128 Li Yen-Liang et al.129 revealed that there are a number of noteworthy differences between breast cancer patients’ naïve lymph nodes (LNs) and tumor-draining lymph nodes (TDLNs) and found that CD4+ and CD8+ T cells showed upregulated angiogenesis pathway genes and higher treg-associated genes. Here, CD4 is linked to breast cancer.