SERPINA5 and age-related macular degeneration: Subcutaneous fat and visceral fat are physiologically different: several groups have reported differential gene expressions of abdominal subcutaneous and visceral fat cells among humans.46 47 SERPINA5, a proinflammatory and coagulation-modulating gene, is expressed 17-fold greater in the subcutaneous abdominal tissue relative to visceral abdominal tissue47; significant upregulation of SERPINA5 has been also found in eyes at early stages of AMD.48