While no significant correlation between YAP1 mRNA expression levels with NXP900 sensitivity was observed (Fig. S4, A and C), higher expression levels of the downstream transcription factor of the Hippo pathway, TEAD2, strongly correlated with NXP900 sensitivity across the ESCC panel, while expression of two other Hippo mediators, AJUBA and DCHS1, showed a clear but non-significant trend (Fig. S4, B and D). This evidence concerns the gene DCHS1 and esophageal squamous cell carcinoma.