This was shown by the similar accelerated loss of survival by both fly lines after exposure to either classical BSE or vCJD prions; the similar incubation times for bovine PrP transgenic mice inoculated with M129 or V129 human PrP Drosophila-passaged vCJD; and the observation of authentic vCJD prion strain propagation in both fly lines. The gene discussed is PRNP; the disease is variant Creutzfeldt-Jakob disease.