Low-impact variants are known to be involved in the same pathway development of metabolic syndromes reflecting the small effect of the coinheritance of variants, including diabetes, because of the accumulation of burden (16); (ii) The transcripts of HNF1A include the Matched Annotation from the NCBI and EMBL-EBI (MANE) Select transcript ‘NM_000545.5’ and minor transcript ‘NM_001306179.2’. Here, HNF1A is linked to diabetes mellitus.