To further study HCG18/miR-103a-3p/HMGA2 axis in AD, si-HCG18 + oe-NC, si-HCG18 + oe-HMGA2, miR-103a-3p mimic + oe-NC or miR-103a-3p mimic + oe-HMGA2 were transfected into VSMCs. Here, HMGA2 is linked to Alzheimer disease.