The abbreviations used are: 2-PG, 2-phosphoglycerate; 2-/3-PG, a mixture of 2-PG and 3-phosphoglycerate; DHAP, dihydroxyacetone phosphate; ENO2, human enolase 2; F6P, fructose 6-phosphate; G6P, glucose 6-phosphate; G6PDH, glucose 6-phosphate dehydrogenase; GBM, glioblastoma multiforme; Gly3P, glycerol 3-phosphate; HEPTA, (1-hydroxy-2-oxoazepan-3-yl) phosphonic acid; HEX, (1-hydroxy-2-oxopiperidin-3-yl) phosphonic acid; NfENO, N. fowleri enolase; SF2312, (1,5-dihydroxy-2-oxopyrrolidin-3-yl) phosphonic acid. The gene discussed is ENO2; the disease is glioblastoma.