HBA2 and Cowden syndrome 1: In this study, we analyzed the link between epigenetics and the HbH-CS phenotype using the human m6A-mRNA and lncRNA epitranscriptomic microarray data, isolated nucleated red blood cells (NRBCs), and reticulocytes from the peripheral blood of HbH thalassemia as well as healthy controls to validate the chip results in clinical samples and further clarify the function and mechanism of METTL16 in vitro using K562 cells.