Deregulation of RIPK1- and RIPK3-involved signaling cascades have been linked to inflammatory bowel disease, rheumatoid arthritis, autoimmune conditions, and neuroinflammatory diseases such as Alzheimer’s and Parkinson’s disease (Martens et al., 2020, Li et al., 2019, Speir et al., 2021, Clucas and Meier, 2023). Here, RIPK1 is linked to inflammatory bowel disease.