Given the discovery of LKB1 inactivating mutations in diseases like PJS, NSCLC, and colorectal cancer, there is a growing interest in exploring strategies to therapeutically restore the function of mutated LKB1 (Sanchez-Cespedes, 2007, Launonen, 2005, Kitajima et al., 2019). Here, STK11 is linked to colorectal cancer.