One such mouse model is the REVERSA mouse (Ldlr−/−; Apob100/100; Mttpfl/fl; Mx1Cre+/+) which is a model of human familial hypercholesterolemia driven by loss of the LDL receptor and expression of Apob100 (Lieu et al. 2003). The gene discussed is LDLR; the disease is familial hypercholesterolemia.