APOB and atherosclerosis: Additionally, in this mouse model, cholesterol levels can be normalized by the induction of the Mx1-cre transgene (by polyI-polyC (pI:pC) injection) resulting in excision of Mttp (required for ApoB secretion) leading to a fall in plasma LDL and VLDL levels and atherosclerosis regression (Lieu et al. 2003), with loss of monocyte-derived cells from the plaque (Feig et al. 2011a; Parathath et al. 2011).