Mehrad et al. [7] recently reported deleterious mutations in three genes, Zinc Finger Protein 717 gene (ZNF717), Facioscapulohumeral muscular dystrophy-1 gene (FRG1), and cell division cycle 27 (CDC27), and abnormal copy number loss in chromosomes 8 and 6 by whole genome sequencing in CFT patients, suggesting that these molecular-level changes may contribute to the genesis of CFTs. The gene discussed is FRG1; the disease is calcifying fibrous tumor.