Recently, a whole exosome sequencing of patients with diffuse idiopathic skeletal hyperostosis and CPPD suggests an association with variants of a new gene, PPP2R2D. This gene encodes a serine/threonine protein phosphatase that regulates basal cellular activities by dephosphorylating substrates. The gene discussed is PPP2R2D; the disease is diffuse idiopathic skeletal hyperostosis.