COL15A1 expression levels were correlated with OS in brain lower-grade glioma (LGG) (p < 0.001), LIHC (p < 0.001), adrenocortical carcinoma (ACC) (p < 0.001), CHOL (p = 0.042), KICH (p < 0.001), KIRP (p < 0.001), LUAD (p = 0.041), mesothelioma (MESO) (p < 0.001), PRAD (p = 0.025), READ (p < 0.001), THYM (p = 0.013) as shown by cox proportional hazard model analysis in Fig. 3A. Moreover, in ACC, CHOL, KICH, KIRP, LIHC, MESO, PRAD, COL15A1 was a high-risk gene, however, it was a low-risk gene in READ and THYM. This evidence concerns the gene COL15A1 and reading.