COL15A1 was observed to have an elevated expression in several cancers, including cholangiocarcinoma (CHOL), glioblastoma multiforme (GBM), colon adenocarcinoma (COAD), thyroid carcinoma (THCA), head and neck squamous cell carcinoma (HNSC), esophageal carcinoma (ESCA), lung adenocarcinoma (LUAD), kidney renal clear cell carcinoma (KIRC), liver hepatocellular carcinoma (LIHC) kidney chromophobe (KICH), stomach adenocarcinoma (STAD), Sarcoma (SARC). Here, COL15A1 is linked to head and neck squamous cell carcinoma.