The roles of autophagy in cellular proliferation, differentiation, and cell death have been established in NB tumorigenesis and progression.36,37 Numerous studies have raised the potential of modulating the autophagic degradation of cell cycle-related protein, such as CDK2, cyclin D1, to promote drugs-induced antiproliferation effect.38,39 However, the roles and effects of autophagic degradation of CDK4 remain to be poorly understood in NB cells. This evidence concerns the gene CCND1 and neuroblastoma.