LRRK2, GD-related GBA1 and PRKN variants accounted for a significantly higher (P < 0.00001) percentage of familial than sporadic PD patients (LRRK2, 5.04% versus 2.36%; GD-related GBA1 variants, 7.04% versus 4.84%; PRKN, 1.68% versus 0.72%, respectively; Supplementary Table 10). This evidence concerns the gene GBA1 and Parkinson disease.