For instance, DEPDC1B regulates the progression of human chordoma by influencing the ubiquitination of baculovirus apoptosis repeat inhibitor 5 (BIRC5) through the ubiquitin‐binding enzyme E2T (UBE2T);8 in bladder cancer, DEPDC1B and SHC1 collectively serve as tumor promoters, impacting cell proliferation, apoptosis, and migration;9 DEPDC1B regulates the development of hepatocellular carcinoma by controlling cell proliferation, apoptosis, the cell cycle, and cell migration. Here, DEPDC1B is linked to chordoma.