The lack of cytosolic serpins in serpina3g-KO macrophages did not significantly affect the production of type I IFN in response to infection (Fig. S2), and similar to the situation in IFNAR-KO macrophages (Fig. 2C), the production of cathepsin B was unaffected in serpina3g-KO cells (Fig. 2F). The gene discussed is IFNAR1; the disease is infection.