Consequently, these findings indicate that ozenoxacin and other topical antimicrobials, such as nadifloxacin and clindamycinantiacne, exhibit antiacne properties not only through their antimicrobial effects against C. acnes but also by suppressing sebaceous lipogenesis in sebocytes influenced by androgen, insulin, and IGF‐I, which are implicated in adolescent acne. This evidence concerns the gene INS and acne.