Furthermore, we observed that overexpression of EGL-8 was beneficial to the survival of rab-10(ok1494) mutants during infection (Fig. S6A), as manifested by a marked rise in irg-4p::gfp (Fig. S6B and S6Bʹ), suggesting that EGL-8 plays a fundamental role in RAB-10-mediated innate immune response. The gene discussed is RAB10; the disease is infection.