In the PIN data set, direct interventions for CAD and related risk factors were mainly selected, including high-ceiling diuretics, statins, ace inhibitors, angiotensin II receptor blockers (plain and combinations), direct factor Xa inhibitors, vasodilators, antianemic preparations, antithrombotic agents, and other lipid-modifying agents, addressing heart failure, cholesterol management, blood pressure control, anticoagulation, anemia, and blood flow. Here, TNXA is linked to heart failure.