Recent work also revealed a role for IL-1β in promoting MPN disease initiation in JAK2V617F HSCs by enhancing their early expansion in the BM (86), mirroring a previous study in which JAK2V617F hematopoietic cells exhibited increased IL-1β secretion, contributing to sympathetic nerve damage and subsequent MSC attrition in the BM niche (86, 87). The gene discussed is IL1B; the disease is myeloproliferative disorder.