Analysis for CHIP mutations in the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS) clinical trial cohort (ClinicalTrials.gov NCT01327846), in which canakinumab (anti–IL-1β antibody) was administered to patients with prior myocardial infarction, revealed decreased subsequent major adverse cardiovascular events (MACEs) in subjects with TET2 mutations relative to those without CHIP (91). The gene discussed is STUB1; the disease is myocardial infarction.