Short‐term inhibition of S100A8/A9 production by neutrophils, a significant reduction in the myocardial infarct area, and an increase in the LVEF were found upon administration of intravenous metoprolol (a β‐blocker) early in myocardial ischemia–reperfusion without significant adverse events within 24 h. Here, S100A8 is linked to myocardial infarction.