CTLA4 and penile cancer: NCT03333616 reported that the combination of nivolumab (anti-PD-1) and ipilimumab (anti-CTLA-4) did not show a treatment response in 5 penile cancer patients (Objective response rate: 16%) (51), but the same combination regimen demonstrated a significant therapeutic response in another case of metastatic penile cancer progressing after chemotherapy (52).