Additionally, TAMs exposed to VEGF and basic fibroblast growth factor can directly form capillary-like blood vessels by acquiring endothelial cell markers (42–44); Moreover, TAMs induce immunosuppression by downregulating IFN-γ, inhibiting MHC Class II molecule expression to limit effector T cell function, and modulating immunosuppression through the macrophage immune checkpoint CD47-SIRPα (29, 41, 45, 46); Studies also indicate that TAMs contribute to increased drug resistance in MM cells (47, 48). The gene discussed is IFNG; the disease is Miyoshi myopathy.