CXCR4 and Miyoshi myopathy: They promote MM cell proliferation by upregulating secretion of IL-6 and IL-10 (36–38), and enhance migration by inducing cytokine-mediated vascular leakage and downregulating CD138 and C-X-C motif chemokine receptor 4 (CXCR4), thus reducing cell adhesion (39–41).