The c-ERBB-1 proto-oncogene encodes EGFR, and while in the normal pancreas, c-ERBB-1 is expressed exclusively in the islets of Langerhans, human pancreatic cancer cell lines frequently demonstrate its overexpression, which is observed in up to 85% of ductal adenocarcinomas (98). Here, EGFR is linked to familial pancreatic carcinoma.