TWIST1 and familial pancreatic carcinoma: Comparably, whereas Twist expression is enhanced under hypoxic conditions, pancreatic cancer cell lines such as PANC-1, MiaPaCa-2, Capan-1, AsPC-1, and HPAF-2 cells exhibit low Twist expression, suggesting a possible role for Twist in the invasive nature of pancreatic tumors (222).