AIF1 and brain aneurysm: After translocation from mitochondria to the nucleus, AIF1 can induce DNA fragmentation and cell apoptosis through a caspase-independent mechanism, leading to apoptosis within the cell or affecting cell survival by modulating mitochondrial function (29, 30), and the mitochondria-necrotic apoptosis axis is one of the pathogenic mechanisms of cerebral aneurysms (8).