HEY2 and skin basal cell carcinoma: RT-qPCR analysis revealed that the follow-up biopsies had elevated expression (>1.5-fold change) of PTCH1 (hedgehog), HEY2 (Notch), LGR6 (Wnt), FZD2 (Notch), LEF1 (Wnt), ALCAM (Wnt), and RUNX1 (Notch/Wnt) compared with superficial and deep BCC debulk tissue (Figure 2b).