Figure 1 shows an artist’s illustration of the DeltaRex-G retrovector, depicting its integral tumor-targeting function and the basic molecular mechanisms enforcing the expression of a cytocidal dominant-negative (dnG1) trans-gene, which blocks CCNG1/cyclin G1-dependent pathways of cell activation, proliferative competence, and survival functions. The gene discussed is CCNG1; the disease is neoplasm.