Mutations in proto-oncogene IDH1 and IDH2, are usually found in glioma and acute myeloid leukemia (AML), resulting in a hypermethylated profile that confer a selective advantage to the mutated subpopulation of cells, in term of growth rate and stemness capability (Turcan et al., 2018). This evidence concerns the gene IDH2 and acute myeloid leukemia.