Among the natural non-nucleoside DNMT inhibitors, EGCG (epigallocatechin-3 gallate), a polyphenol derived from green tea demethylates the promoter of several genes such as p16 (INK4a), RAR (retinoic acid receptor beta), human mutL homologue 1 (hMLH1) in cancer cell lines derived from colon, prostate and esophageal tumors (Fang et al., 2003). Here, CDKN2A is linked to cancer.