ACE2 deficiency has been directly linked to defects in Insulin secretion (Niu et al., 2008) and interestingly, B1R as well as CPN1, the enzyme that converts BK into the B1R ligand DABK, have been researched as preclinical targets in the context of Diabetes (El Akoum et al., 2017; Haddad and Couture, 2017). The gene discussed is INS; the disease is diabetes mellitus.