ACE2 reduces cytokine release and inhibits signaling pathways of tissue fibrosis in experimental models of obesity (Rodrigues Prestes et al., 2017) and its deficiency in epicardial adipose tissue worsens inflammation and cardiac dysfunction in response to diet-induced obesity (Patel et al., 2016). This evidence concerns the gene ACE2 and obesity due to melanocortin 4 receptor deficiency.