The circulating level of inactive MGP (dephosphorylated and uncarboxylated MGP, dp-ucMGP) is related to the severity of aortic calcification in patients with CKD (Schurgers et al., 2010), and predicts long-term mortality in patients with calcific valvular aortic stenosis (Ueland et al., 2010). The gene discussed is MGP; the disease is chronic kidney disease.