VEGF and PEDF are secreted by retinal pigment epithelial cells (5), and according to the conclusions drawn, it can be seen that degenerative changes in retinal pigment epithelial thickness in high myopia and the degeneration of the retinal pigment epithelial layer lead to photoreceptor degeneration (27), which subsequently affects visual function. The gene discussed is SERPINF1; the disease is myopia.