Interestingly, in an effort to characterize the protein composition of SGs, a comprehensive analysis of the available dataset by Asadi et al. revealed that many hnRNPs localized to SGs in various neurodegenerative conditions including the ALS/FTD continuum, Alzheimer’s disease (AD), Multiple sclerosis (MS) and Motor neuron disease (MND): TDP-43 and hnRNP P2 (FUS) are found in many if not all pathological conditions, while hnRNP A2/B1 and hnRNP A0 are associated to SG in ALS and AD, respectively (Asadi et al., 2021). Here, FUS is linked to early-onset autosomal dominant Alzheimer disease.