TARDBP and amyotrophic lateral sclerosis: As this intricate interplay between TDP-43 and other hnRNPs plays a critical role in co-regulating RNA splicing targets (see section 4), and as expression levels of certain hnRNPs vary significantly among individuals with FTLD-TDP and control patients (Mohagheghi et al., 2016), TDP-43-hnRNPs cooperation could be central in ALS-FTD disorder.