TARDBP and amyotrophic lateral sclerosis: To date, genetic studies have linked 4 hnRNPs [A1, A2/B1, FUS (hnRNP P2) and TDP-43] to neurodegenerative diseases, including Amyotrophic lateral sclerosis (ALS), Frontotemporal dementia (FTD) and Frontotemporal lobar degeneration (FTLD) that form a clinical disease continuum from motor neuron degenerative disease to dementia (Van Langenhove et al., 2012; Purice and Taylor, 2018).