TARDBP and Alzheimer disease: (2) A proteomic study of 16 human brain tissues from AD patients and age-matched controls revealed a significantly increased expression of hnRNPs C, K, L, M, R, U and UL2, in AD, while the expression level of TDP-43, and hnRNPs AB, A3, DL, and E1 (PCBP1) were decreased (Zhang et al., 2018).