TARDBP and amyotrophic lateral sclerosis: Specifically, the mislocalization of TDP-43 in the cytoplasm induces aberrant splicing of several genes: (i) activation of a cryptic splice site in the first intron of STMN2 gene (encoding Stathmin-2) that compromises axon repair following motor neuron injury in ALS (Klim et al., 2019; Melamed et al., 2019; Baughn et al., 2023), (ii) insertion of a cryptic exon between exon 20 and 21 within the UNC13A transcript, a gene that plays important roles in neurotransmitter release at synapses.