TARDBP and frontotemporal dementia: To note, although not associated to any TDP-43 variants, FTLD-TDP, or frontotemporal lobar degeneration with TDP-43 pathology, that is a subtype of FTD, is characterized by the presence of abnormal accumulations of aggregated cytoplasmic TDP-43 in neurons and glia (Chen-Plotkin et al., 2010).