Among these, hnRNP G (RBMX), hnRNP M, and hnRNP Q, facilitate the inclusion of exon 7 in SMN2. Conversely, the depletion of hnRNPs A1/A2 promotes exon 7 inclusion in SMN2. Remarkably, SMN2 is almost identical to SMN1 gene, which is mutated in SMA. The gene discussed is SMN2; the disease is proximal spinal muscular atrophy.