Second, as extensively reviewed by Corsi et al. (2022), there are many hnRNP proteins [D, A3, H1, C, R, A2/B1, A1, G (RBMX), E2 (PCBP2), I (PTBP1), and PTBP2] that intricately regulate MAPT splicing, impacting the balance between various tau isoforms crucial for normal neuronal function and implicated in neurodegenerative diseases like Alzheimer’s disease. Here, MAPT is linked to Alzheimer disease.