Patients with a high cortisol level following 1 mg dexamethasone suppression test (DST) and suppressed ACTH level (<10 pg/mL) plus one more positive test result compatible with hypercortisolemia (high cortisol level after two days of 2 mg DST, high 24-hour urinary free cortisol (UFC) level, low dehydroepiandrosteronesulfate (DHEA-S), high late-night salivary cortisol, or midnight serum cortisol level), but no symptoms or signs compatible with Cushing’s syndrome were considered to have SH. The gene discussed is POMC; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.