Also, in Fatemi et al.'s research (2019) with black seed in 42 patients of all types of hypothyroidism CHL and FBS reduction was significant in drug group with negative anti-thyroid peroxidase (ATPO) antibody, while in our research reduction of CHL was not significant and FBS changes were within the normal range in the intervention group. Here, ATP5PO is linked to classic Hodgkin lymphoma.