As was seen in this present study, DHT/estradiol valerate model of BPH induction triggered peroxidation of lipids and oxidant stress in the prostate of the BPH group as evidenced from the decreased concentrations of SOD, GPx, CAT and GSH but increased MDA concentration in the prostate of the BPH group. The gene discussed is SOD1; the disease is benign prostatic hyperplasia.