So far, the best documented lncRNA deregulation in AD concerns lncRNAs which are antisense transcripts of mRNAs derived from known AD-related genes, as BACE1-AS, 51A, 17A and BC200, which have been found to be directly involved in Aβ deposition, Tau iper-phosphorylation and neuroinflammation (Faghihi et al., 2008; Ciarlo et al., 2012; Ahmadi et al., 2020; Bagyinszky et al., 2020). Here, MAPT is linked to Alzheimer disease.