APP and Alzheimer disease: Another study on APP/PS1 mice (an animal model of AD) examined the effects of CIH on cognition and hippocampal function and found that CIH induced long-term potentiation dysfunction of the hippocampus in APP/PS1 mice as they found the decrease of N-methyl-D-aspartic acid receptor (NMDAR) NR1 subunit and postsynaptic density 95 (PSD95) in the hippocampus of APP/PS1 mice after CIH treatment (Li and Ye, 2024).