Due to the fact that ischemia-reperfusion injury concurrently triggers neuropathology and gene expression associated with AD, including the development of amyloid plaques, neurofibrillary tangles, and hippocampal atrophy, which are crucial for the progression of AD (Pluta and Ulamek-Koziol, 2021), the protective role of HIF-1α against ischemia-reperfusion injury indirectly suggests its protective effects against AD. This evidence concerns the gene HIF1A and Alzheimer disease.