Indeed, several preclinical studies have shown that in a murine model of BRAF-mutated melanoma, treatment with BRAF inhibitors improves the antitumor effects of TCR-engineered ACT, increases the expression of melanoma-associated antigens, and decreases the expression of immunosuppressive cytokines (Koya et al., 2012; Frederick et al., 2013). The gene discussed is BRAF; the disease is melanoma.