CD274 and melanoma: The RELATIVITY-020 study conducted by Ascierto et al. (2023b) on 518 melanoma patients showed that the combination of relatlimab and nivolumab had satisfactory and durable clinical results in patients with metastatic melanoma that were previously treated with PDL-1 inhibitors; indeed, the median PFS here ranged from 2.1 to 3.2 months (95% CIs, 1.9 to 3.5 and 1.9 to 3.6, respectively), and the PFS rates at 6 months ranged from 27.7% to 29.1% (95% CIs, 20.5 to 35.4 and 24.2 to 34.1, respectively) across patient cohorts characterized by different treatment doses (Ascierto et al., 2023b).