IL1B and epilepsy: Increases in another CCL, CCL2, and its corresponding receptor CCR2, have also been found in human TLE (Wu et al., 2008) as well as pilocarpine (Foresti et al., 2009; Mercado-Gómez et al., 2014; Arisi et al., 2015) and KA (Manley et al., 2007; Tian et al., 2017) induced epilepsy, where it plays a crucial role in inflammation, neuronal death, and activation of the downstream effectors STAT3 and IL-1β (Tian et al., 2017).