IL33 and epilepsy: Astrocytically-released IL-33 has also been found to drive synaptic engulfment by microglia (Vainchtein et al., 2018) and microglial activation has been linked to epilepsy in general (Shapiro et al., 2008; Hiragi et al., 2018) [see (Andoh and Koyama, 2021) for review of microglia and plasticity].