The molecular cloning of the first human cyclin G-type gene (Wu et al., 1994), followed by studies of its overexpression and survival function in osteosarcoma cells—which lack a functional/wild type p53 (TP53) tumor suppressor (Wu et al., 1995)—provided a conceptual missing link in the proximal/initiating/transcriptional pathways driving the immediate early molecular genetics of neoplastic transformation and oncogenesis. This evidence concerns the gene TP53 and osteosarcoma.